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Article

Sustained notch signaling inhibition with a gamma-secretase inhibitor prevents traumatic heterotopic ossification

31 Jul 2023

Abstract excerpt

Background: Traumatic heterotopic ossification (THO) is a devastating sequela following traumatic injuries and orthopedic surgeries. To date, the exact molecular mechanism of THO formation is still unclear, which hinders the development of effective treatments. The process of THO formation is believed to recapitulate a series of spatiotemporal cellular and signaling events that occur during skeletal development....

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PMID: 37575153
DOI: 10.1016/j.jot.2023.06.004

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