Article
ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
Pain - 1 Jan 2023
Yu Xiaobing, Ton Amy N, Niu Zejun, Morales Blanca M, Chen Jiadong, Braz Joao, Lai Michael H, Barruet Emilie, Liu Hongju, Cheung Kin, Ali Syed, Chan Tea, Bigay Katherine, Ho Jennifer, Nikolli Ina, Hansberry Steven, Wentworth Kelly, Kriegstein Arnold, Basbaum Allan, Hsiao Edward C
Abstract excerpt
ABSTRACT: Altered bone morphogenetic protein (BMP) signaling is associated with many musculoskeletal diseases. However, it remains unknown whether BMP dysfunction has direct contribution to debilitating pain reported in many of these disorders. Here, we identified a novel neuropathic pain phenotype in patients with fibrodysplasia ossificans progressiva (FOP), a rare autosomal-dominant musculoskeletal disorder...
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