Article
Genetic association study of common mitochondrial variants on body fat mass.
PloS one - 1 Jan 2011
Yang Tie-Lin, Guo Yan, Shen Hui, Lei Shu-Feng, Liu Yong-Jun, Li Jian, Liu Yao-Zhong, Yu Na, Chen Jia, Xu Ting, Cheng Yu, Tian Qing, Yu Ping, Papasian Christopher J, Deng Hong-Wen
Abstract excerpt
Mitochondria play a central role in ATP production and energy metabolism. Previous studies suggest that common variants in mtDNA are associated with several common complex diseases, including obesity. To test the hypothesis that common mtDNA variants influence obesity-related phenotypes, including BMI and body fat mass, we genotyped a total of 445 mtSNPs across the whole mitochondrial genome in a large sample of...
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