Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population.

Human genetics - 1 Oct 2017

Zheng Hong-Xiang, Li Lei, Jiang Xiao-Yan, Yan Shi, Qin Zhendong, Wang Xiaofeng, Jin Li

Abstract excerpt

Considerable attention has been focused on the effect of deleterious mutations caused by the recent relaxation of selective constraints on human health, including the prevalence of obesity, which might represent an adaptive response of energy-conserving metabolism under the conditions of modern society. Mitochondrial DNA (mtDNA) encoding 13 core subunits of oxidative phosphorylation plays an important role in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Asian People
Share to Bone Density

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Genome, Mitochondrial

Share to Haplotypes

Share to Obesity

Source

Identifiers

PMID: 28799012
DOI: 10.1007/s00439-017-1829-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population.PMID 28799012Read ↗

A common polymorphism is associated with body mass index in Uyghur population.Semantic proximity Read ↗

Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population.Semantic proximity Read ↗

Mitochondrial haplogroup R offers protection against obesity in Kuwaiti and Qatari populations.Semantic proximity Read ↗

Natural selection shaped the protective effect of the mtDNA lineage against obesity in Han Chinese populations.Semantic proximity Read ↗

Single nucleotide polymorphisms of thrifty genes for energy metabolism: evolutionary origins and prospects for intervention to prevent obesity-related diseases.Semantic proximity Read ↗

Delineation of Mitochondrial DNA Variants From Exome Sequencing Data and Association of Haplogroups With Obesity in KuwaitSemantic proximity Read ↗

Worldwide Increase of Obesity Is Related to the Reduced Opportunity for Natural Selection.Semantic proximity Read ↗

Genetic association study of common mitochondrial variants on body fat mass.Semantic proximity Read ↗

A global evolutionary and metabolic analysis of human obesity gene risk variants.Semantic proximity Read ↗

Comprehensive association testing of common mitochondrial DNA variation in metabolic disease.Semantic proximity Read ↗

[The Role of Natural Selection in the Formation of the Genetic Structure of Populations by SNP Markers in Association with Body Mass Index and Obesity].Semantic proximity Read ↗

Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease riskSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.