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Article

Natural selection shaped the protective effect of the mtDNA lineage against obesity in Han Chinese populations.

Journal of genetics and genomics = Yi chuan xue bao - 1 Apr 2025

Chen Ziwei, Chen Lu, Tan Jingze, Mao Yizhen, Hao Meng, Li Yi, Wang Yi, Li Jinxi, Wang Jiucun, Jin Li, Zheng Hong-Xiang

Abstract excerpt

Mitochondria play a key role in lipid metabolism, and mitochondrial DNA (mtDNA) mutations are thus considered to affect obesity susceptibility by altering oxidative phosphorylation and mitochondrial function. In this study, we investigate mtDNA variants that may affect obesity risk in 2877 Han Chinese individuals from 3 independent populations. The association analysis of 16 basal mtDNA haplogroups with body mass...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38880354
DOI: 10.1016/j.jgg.2024.06.005

Genes

DACT2
PIEZO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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