Article
Mitochondria-wide association study of common variants in osteoporosis.
Annals of human genetics - 1 Sept 2011
Guo Yan, Yang Tie-Lin, Liu Yao-Zhong, Shen Hui, Lei Shu-Feng, Yu Na, Chen Jia, Xu Ting, Cheng Yu, Tian Qing, Yu Ping, Deng Hong-Wen
Abstract excerpt
Mitochondrial DNA (mtDNA) variants are involved in the pathogenesis of human complex diseases, especially for age-related disorders, including osteoporosis. However, the role of mtDNA variants in osteoporosis is largely unknown. In this study, we performed a mitochondria-wide association study for osteoporosis in a large sample of 2286 unrelated Caucasian subjects. A total of 445 mtSNPs were genotyped and 72...
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