Article
Mitochondrial DNA variants in obesity.
PloS one - 1 Jan 2014
Knoll Nadja, Jarick Ivonne, Volckmar Anna-Lena, Klingenspor Martin, Illig Thomas, Grallert Harald, Gieger Christian, Wichmann Heinz-Erich, Peters Annette, Wiegand Susanna, Biebermann Heike, Fischer-Posovszky Pamela, Wabitsch Martin, Völzke Henry, Nauck Matthias, Teumer Alexander, Rosskopf Dieter, Rimmbach Christian, Schreiber Stefan, Jacobs Gunnar, Lieb Wolfgang, Franke Andre, Hebebrand Johannes, Hinney Anke
Abstract excerpt
Heritability estimates for body mass index (BMI) variation are high. For mothers and their offspring higher BMI correlations have been described than for fathers. Variation(s) in the exclusively maternally inherited mitochondrial DNA (mtDNA) might contribute to this parental effect. Thirty-two to 40 mtDNA single nucleotide polymorphisms (SNPs) were available from genome-wide association study SNP arrays...
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