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Article

Serum homocysteine and risk of dementia in Japan.

Journal of neurology, neurosurgery, and psychiatry - 1 May 2020

Chen Sanmei, Honda Takanori, Ohara Tomoyuki, Hata Jun, Hirakawa Yoichiro, Yoshida Daigo, Shibata Mao, Sakata Satoko, Oishi Emi, Furuta Yoshihiko, Kitazono Takanari, Ninomiya Toshiharu

Abstract excerpt

OBJECTIVE: To examine the association between serum total homocysteine levels (tHcy) and dementia risk. METHODS: A total of 1588 Japanese adults aged ≥60 years without dementia were prospectively followed from 2002 to 2012. Cox proportional hazards models and restricted cubic splines were used to estimate the HRs of tHcy levels on the risk of dementia. RESULTS: During the follow-up, 372 subjects developed...

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Identifiers

PMID: 32234968
DOI: 10.1136/jnnp-2019-322366
PMCID: PMC7231445

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