Article
Matrix metalloproteinase 2 genotype is associated with nonanastomotic biliary strictures after orthotopic liver transplantation.
Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2011
Ten Hove W Rogier, Korkmaz Kerem S, op den Dries Sanna, de Rooij Bert-Jan F, van Hoek Bart, Porte Robert J, van der Reijden Johan J, Coenraad Minneke J, Dubbeld Jeroen, Hommes Daniel W, Verspaget Hein W
Abstract excerpt
BACKGROUND: Nonanastomotic biliary strictures (NAS) are a serious complication after orthotopic liver transplantation (OLT). Matrix metalloproteinases (MMPs) are involved in connective tissue remodelling in chronic liver disease and complications after OLT. AIM: To evaluate the relationship between MMP-2 and MMP-9 gene polymorphisms and NAS. METHODS: MMP-2 (-1306 C/T) and MMP-9 (-1562 C/T) gene promoter...
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