Article
Matrix Metalloproteinase Gene Polymorphisms and New-Onset Diabetes After Kidney Transplantation in Korean Renal Transplant Subjects.
Transplantation proceedings - 1 Apr 2016
Ong S, Kang S-W, Kim Y-H, Kim T-H, Jeong K-H, Kim S-K, Yoon Y-C, Seo S-K, Moon J-Y, Lee S-H, Ihm C-G, Lee T-W, Chung J-H
Abstract excerpt
BACKGROUND: New-onset diabetes after transplantation (NODAT) is a serious metabolic complication that may follow renal transplantation. Matrix metalloproteinases (MMPs) contribute to insulin insufficiency and beta-cell dysfunction in a rat model. The MMP-2 concentrations were lower in patients with type 2 diabetes mellitus, and the plasma MMPs levels were related to diabetes. Similar to the pathogenesis of type 2...
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