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Article

The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome

17 Feb 2009

Abstract excerpt

RUNX3 is believed to have tumour suppressor properties in several cancer types. Inactivation of RUNX3 has been shown to occur by methylation-induced transcriptional silencing and by mislocalization of the protein to the cytoplasm. The aim of this study was to examine the clinical significance of RUNX3 expression in a large series of colorectal cancers using immunohistochemistry and tissue arrays. With advancing...

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PMID: 19223906
DOI: 10.1038/sj.bjc.6604899

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