Article
Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells.
Investigative ophthalmology & visual science - 22 Aug 2011
Ogata-Iwao Minako, Inatani Masaru, Iwao Keiichiro, Takihara Yuji, Nakaishi-Fukuchi Yuko, Irie Fumitoshi, Sato Shigeru, Furukawa Takahisa, Yamaguchi Yu, Tanihara Hidenobu
Abstract excerpt
PURPOSE. Heparan sulfate (HS) is abundantly expressed in the developing neural retina; however, its role in the intraretinal axon guidance of retinal ganglion cells (RGCs) remains unclear. In this study, the authors examined whether HS was essential for the axon guidance of RGCs toward the optic nerve head. METHODS. The authors conditionally ablated the gene encoding the exostosin-1 (Ext1) enzyme, using the...
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