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Article

BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention.

Experimental cell research - 15 Aug 2004

Fabbro Megan, Schuechner Stefan, Au Wendy W Y, Henderson Beric R

Abstract excerpt

BRCA1 is involved in maintaining genomic integrity and, as a regulator of the G2/M checkpoint, contributes to DNA repair and cell survival. The overexpression of BRCA1 elicits diverse cellular responses including apoptosis due to the stimulation of specific signaling pathways. BRCA1 is normally regulated by protein turnover, but is stabilized by BARD1 which can recruit BRCA1 to the nucleus to form a ubiquitin E3...

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Source

Identifiers

PMID: 15265711
DOI: 10.1016/j.yexcr.2004.05.004

Genes

BRCA1
BARD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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