Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Damage Induces p53-dependent BRCA1 Nuclear Export

25 Jun 2004

Abstract excerpt

The tumor suppressor gene BRCA1 plays an important role in the response to DNA damage. BRCA1 function is regulated by a variety of mechanisms including transcriptional control, phosphorylation, and protein-protein interactions. Recent studies have shown that BRCA1 is a nuclear-cytoplasmic shuttle protein. Its subcellular localization is controlled by a nuclear localization signal-mediated nuclear import via the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Nuclear Structure and Function

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15087457
DOI: 10.1074/jbc.m404137200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Damage Induces p53-dependent BRCA1 Nuclear ExportPMID 15087457Read ↗

p53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage.Semantic proximity Read ↗

A nuclear function for the tumor suppressor BRCA1.Semantic proximity Read ↗

Effector Genes Altered in MCF-7 Human Breast Cancer Cells after Exposure to Fractionated Ionizing RadiationSemantic proximity Read ↗

Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells.Semantic proximity Read ↗

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.Semantic proximity Read ↗

Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells.Semantic proximity Read ↗

Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase.Semantic proximity Read ↗

Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination.Semantic proximity Read ↗

An amino-terminal motif functions as a second nuclear export sequence in BRCA1.Semantic proximity Read ↗

Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci.Semantic proximity Read ↗

Control of p53 nuclear accumulation in stressed cells.Semantic proximity Read ↗

Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.