Article
Regulation of p53 tetramerization and nuclear export by ARC.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2007
Foo Roger S-Y, Nam Young-Jae, Ostreicher Marc Jason, Metzl Mark D, Whelan Russell S, Peng Chang-Fu, Ashton Anthony W, Fu Weimin, Mani Kartik, Chin Suet-Feung, Provenzano Elena, Ellis Ian, Figg Nichola, Pinder Sarah, Bennett Martin R, Caldas Carlos, Kitsis Richard N
Abstract excerpt
Inactivation of the transcription factor p53 is central to carcinogenesis. Yet only approximately one-half of cancers have p53 loss-of-function mutations. Here, we demonstrate a mechanism for p53 inactivation by apoptosis repressor with caspase recruitment domain (ARC), a protein induced in multiple cancer cells. The direct binding in the nucleus of ARC to the p53 tetramerization domain inhibits p53...
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