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Article

Nuclear-cytoplasmic translocation of BARD1 is linked to its apoptotic activity.

Oncogene - 29 Apr 2004

Jefford Charles Edward, Feki Anis, Harb Jean, Krause Karl-Heinz, Irminger-Finger Irmgard

Abstract excerpt

The tumor suppressor protein BARD1 plays a dual role in response to genotoxic stress: DNA repair as a BARD1-BRCA1 heterodimer and induction of apoptosis in a BRCA1-independent manner. We have constructed a series of BARD1 deletion mutants and analysed their cellular distribution and capacity to induce apoptosis. As opposed to previous studies suggesting an exclusively nuclear localization of BARD1, we found, both...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15077185
DOI: 10.1038/sj.onc.1207427

Genes

BARD1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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