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Article

Inhibition of STAT3 by S3I-201 suppress peritoneal fibroblast phenotype conversion and alleviate peritoneal fibrosis.

Journal of cellular and molecular medicine - 1 May 2024

Song Qianhui, Li Han, Yan Hao, Yu Zanzhe, Li Zhenyuan, Yuan Jiangzi, Jiang Na, Ni Zhaohui, Gu Leyi, Fang Wei

Abstract excerpt

Peritoneal fibrosis is a common pathological response to long-term peritoneal dialysis (PD) and a major cause for PD discontinuation. Understanding the cellular and molecular mechanisms underlying the induction and progression of peritoneal fibrosis is of great interest. In our study, in vitro study revealed that signal transducer and activator of transcription 3 (STAT3) is a key factor in fibroblast activation...

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Identifiers

PMID: 38780509
DOI: 10.1111/jcmm.18381
PMCID: PMC11114217

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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