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Article

Packaging signals in the 5'-ends of influenza virus PA, PB1, and PB2 genes as potential targets to develop nucleic-acid based antiviral molecules.

Antiviral research - 1 Oct 2011

Giannecchini Simone, Wise Helen M, Digard Paul, Clausi Valeria, Del Poggetto Edoardo, Vesco Liberio, Puzelli Simona, Donatelli Isabella, Azzi Alberta

Abstract excerpt

In a previous study a 15-mer phosphorothioate oligonucleotide (S-ON) derived from the packaging signal in the 5' end of segment 1 (PB2) of influenza A virus (designated 5-15b) proved markedly inhibitory to virus replication. Here we investigated whether analogous inhibitory S-ONs targeting the 5' end of segments 2 (PB1) and 3 (PA) could be identified and whether viral resistance to S-ONs can be developed. Similar...

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Identifiers

PMID: 21741410
DOI: 10.1016/j.antiviral.2011.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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