Article
Mutations of the segment-specific nucleotides at the 3' end of influenza virus NS segment control viral replication.
Virology - 2 Jan 2020
Rodriguez Paloma, Marcos-Villar Laura, Zamarreño Noelia, Yángüez Emilio, Nieto Amelia
Abstract excerpt
The vRNAs of influenza A viruses contain 12 and 13 nucleotide-long sequences at their 3' and 5' termini respectively that are highly conserved and constitute the vRNA promoter. These sequences and the next three segment-specific nucleotides show inverted partial complementarity and are followed by several unpaired nucleotides of poorly characterized function at the 3' end. We have performed systematic...
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