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Article

Characterization of nonconservative homologous junctions in mammalian cells.

Molecular and cellular biology - 1 Dec 1990

Desautels L, Brouillette S, Wallenburg J, Belmaaza A, Gusew N, Trudel P, Chartrand P

Abstract excerpt

Homologous recombination in mammalian cells between extrachromosomal molecules, as well as between episomes and chromosomes, can be mediated by a nonconservative mechanism. It has been proposed that the key steps in this process are the generation (by double-strand cleavage) of overlapping homologous ends, the creation of complementary single-strand ends (either by strand-specific exonuclease degradation or by...

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Identifiers

PMID: 2174111
DOI: 10.1128/mcb.10.12.6613-6618.1990
PMCID: PMC362938

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