Article
Characterization of nonconservative homologous junctions in mammalian cells.
Molecular and cellular biology - 1 Dec 1990
Desautels L, Brouillette S, Wallenburg J, Belmaaza A, Gusew N, Trudel P, Chartrand P
Abstract excerpt
Homologous recombination in mammalian cells between extrachromosomal molecules, as well as between episomes and chromosomes, can be mediated by a nonconservative mechanism. It has been proposed that the key steps in this process are the generation (by double-strand cleavage) of overlapping homolo...
Topics
- Animals
- Cell Line
- DNA
- Genes, Viral
- Genetic Variation
- Mice
- Polyomavirus
- Recombination, Genetic
- Restriction Mapping
- Sequence Homology, Nucleic Acid
- Transfection