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Article

Bacteria lacking a multidrug pump: a sensitive tool for drug discovery.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 1998

Hsieh P C, Siegel S A, Rogers B, Davis D, Lewis K

Abstract excerpt

Microorganisms express multidrug resistance pumps (MDRs) that can confound antibiotic discovery. We propose the use of mutants deficient in MDRs to overcome this problem. Sensitivity to quinolones and to amphipathic cations (norfloxacin, benzalkonium chloride, cetrimide, pentamidine, etc.) was increased 5- to 30-fold in a Staphylococcus aureus mutant with a disrupted chromosomal copy of the NorA MDR. NorA was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9618458
DOI: 10.1073/pnas.95.12.6602
PMCID: PMC22572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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