Bacteria lacking a multidrug pump: a sensitive tool for drug discovery.

doi:10.1073/pnas.95.12.6602

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Article

Bacteria lacking a multidrug pump: a sensitive tool for drug discovery.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 1998

Hsieh P C, Siegel S A, Rogers B, Davis D, Lewis K

Abstract excerpt

Microorganisms express multidrug resistance pumps (MDRs) that can confound antibiotic discovery. We propose the use of mutants deficient in MDRs to overcome this problem. Sensitivity to quinolones and to amphipathic cations (norfloxacin, benzalkonium chloride, cetrimide, pentamidine, etc.) was in...

Topics

Anti-Bacterial Agents
Biological Transport
Cations
Drug Resistance, Multiple
Microbial Sensitivity Tests
Mutation
Quinolones
Staphylococcus aureus

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