Quinolone susceptibility of norA-disrupted Staphylococcus aureus.

doi:10.1128/AAC.41.10.2308

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Article

Quinolone susceptibility of norA-disrupted Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Oct 1997

Yamada H, Kurose-Hamada S, Fukuda Y, Mitsuyama J, Takahata M, Minami S, Watanabe Y, Narita H

Abstract excerpt

The MIC of norfloxacin for the norA-disrupted mutant termed RDN1, obtained from quinolone-susceptible Staphylococcus aureus RN4220, was eightfold lower than that for RN4220. The increase in susceptibility was related to an increase of drug accumulation by RDN1. These results indicate that NorA pl...

Topics

4-Quinolones
Anti-Infective Agents
Blotting, Southern
Drug Resistance, Microbial
Genes, Bacterial
Microbial Sensitivity Tests
Mutation
Staphylococcus aureus

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