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Article

Cryptic transcription mediates repression of subtelomeric metal homeostasis genes.

PLoS genetics - 1 Jun 2011

Toesca Isabelle, Nery Camille R, Fernandez Cesar F, Sayani Shakir, Chanfreau Guillaume F

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) prevents the accumulation of transcripts bearing premature termination codons. Here we show that Saccharomyces cerevisiae NMD mutants accumulate 5'-extended RNAs (CD-CUTs) of many subtelomeric genes. Using the subtelomeric ZRT1 and FIT3 genes activated in response to zinc and iron deficiency, respectively, we show that transcription of these CD-CUTs mediates repression at the...

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Identifiers

PMID: 21738494
DOI: 10.1371/journal.pgen.1002163
PMCID: PMC3128112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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