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Synthetic Lethality‐Based Targets and Their Exploration in Tumour Combination Strategies

1 Aug 2025

Abstract excerpt

Synthetic lethality (SL) not only addresses the challenge of drug resistance associated with classical targeted therapies but also offers innovative therapeutic approaches for previously 'undruggable' targets, such as deletion mutations in tumour suppressor genes. Advances in technology have significantly enhanced our understanding of gene-gene interactions in cancer cells, enabling the identification of...

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PMID: 40859871
DOI: 10.1111/jcmm.70756

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