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Article

XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2011

Vaezi Alec, Wang Xiaozhe, Buch Shama, Gooding William, Wang Lin, Seethala Raja R, Weaver David T, D'Andrea Alan D, Argiris Athanassios, Romkes Marjorie, Niedernhofer Laura J, Grandis Jennifer R

Abstract excerpt

PURPOSE: Tumor-specific biomarkers that predict resistance to DNA damaging agents may improve therapeutic outcomes by guiding the selection of effective therapies and limiting morbidity related to ineffective approaches. XPF (ERCC4) is an essential component of several DNA repair pathways and XPF-deficient cells are exquisitely sensitive to DNA damaging agents. The purpose of this study was to determine whether...

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Identifiers

PMID: 21737503
DOI: 10.1158/1078-0432.CCR-11-0086
PMCID: PMC3156890

Genes

ERCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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