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Article

Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins.

The Journal of biological chemistry - 12 Aug 2011

Li Xing, Yeung Darwin F, Fiegen Ann M, Sodroski Joseph

Abstract excerpt

Many tripartite motif (TRIM) proteins self-associate, forming dimers and higher order complexes. For example, dimers of TRIM5α, a host factor that restricts retrovirus infection, assemble into higher order arrays on the surface of the viral capsid, resulting in an increase in avidity. Here we show that the higher order association of different TRIM proteins exhibits a wide range of efficiencies. Homologous...

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Identifiers

PMID: 21680743
DOI: 10.1074/jbc.M111.260406
PMCID: PMC3151041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins.PMID 21680743Read ↗

Retroviral restriction factor TRIM5alpha is a trimer.Semantic proximity Read ↗

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Functional Replacement of the RING, B-Box 2, and Coiled-Coil Domains of Tripartite Motif 5α (TRIM5α) by Heterologous TRIM DomainsSemantic proximity Read ↗

Human Tripartite Motif 5α Domains Responsible for Retrovirus Restriction Activity and SpecificitySemantic proximity Read ↗

The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α.Semantic proximity Read ↗

Unique features of TRIM5α among closely related human TRIM family membersSemantic proximity Read ↗

The antiviral activities of TRIM proteinsSemantic proximity Read ↗

All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction.Semantic proximity Read ↗

TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune SignalingSemantic proximity Read ↗

TRIM5α selectively binds a restriction-sensitive retroviral capsidSemantic proximity Read ↗

A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction.Semantic proximity Read ↗

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