Article
Genetics of Adrenocortical Development and Tumors.
Endocrinology and metabolism clinics of North America - 1 Jun 2017
Lodish Maya
Abstract excerpt
This article links the understanding of developmental physiology of the adrenal cortex to adrenocortical tumor formation. Many molecular mechanisms that lead to formation of adrenocortical tumors have been discovered via next-generation sequencing approaches. The most frequently mutated genes in adrenocortical tumors are also factors in normal adrenal development and homeostasis, including those that alter the...
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