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Article

Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts.

Journal of cellular physiology - 1 Dec 2011

Kawamata Aya, Inoue Akane, Miyajima Daisuke, Hemmi Hiroaki, Mashima Ryuichi, Hayata Tadayoshi, Ezura Yoichi, Amagasa Teruo, Yamanashi Yuji, Noda Masaki

Abstract excerpt

Osteoporosis causes fractures that lead to reduction in the quality of life and it is one of the most prevalent diseases as it affects approximately 10% of the population. One of the important features of osteoporosis is osteopenia. However, its etiology is not fully elucidated. Dok-1 and Dok-2 are adaptor proteins acting downstream of protein tyrosine kinases that are mainly expressed in the cells of...

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Identifiers

PMID: 21732353
DOI: 10.1002/jcp.22909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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