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Article

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis.

Nature medicine - 1 Apr 2005

Wada Teiji, Nakashima Tomoki, Oliveira-dos-Santos Antonio J, Gasser Juerg, Hara Hiromitsu, Schett Georg, Penninger Josef M

Abstract excerpt

Morphogenesis and remodeling of bone involve synthesis of bone matrix by osteoblasts and coordinate resorption of bone by osteoclasts. Defective bone remodeling caused by altered osteoclast activity underlies a multitude of osteopenic disorders. Receptor activator of NF-kappaB (RANK) and its ligand RANKL have been identified as essential factors involved in osteoclast development and bone remodeling, but their...

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Identifiers

PMID: 15750601
DOI: 10.1038/nm1203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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