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Article

Regulation of osteoclast structure and function by FAK family kinases

1 Sept 2012

Abstract excerpt

Osteoclasts are highly specialized cells that resorb bone and contribute to bone remodeling. Diseases such as osteoporosis and osteolytic bone metastasis occur when osteoclast-mediated bone resorption takes place in the absence of concurrent bone synthesis. Considerable effort has been placed on identifying molecules that regulate the bone resorption activity of osteoclasts. To this end, we investigated unique...

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Identifiers

PMID: 22941736
DOI: 10.1189/jlb.0512259

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