Article

FAM98 Family Proteins Play Distinct Roles in Osteoclastogenesis and Bone Resorption

2024-11-01

Abstract excerpt

There are three FAM98 family proteins (FAM98A/B/C) in human and mice. Their physiological functions remain largely unknown. We have previously reported that Fam98a interacts with Plekhm1 in murine osteoclasts and functions in lysosome trafficking/secretion and bone resorption in osteoclasts in vitro. In this study, we found that all three Fam98 genes were expressed in precursor and mature osteoclasts. While knockd...

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Literature Corpus work: 21f42d9b-5070-5355-836f-0226d96e1651
DOI: 10.20944/preprints202410.2584.v1

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