Article
The Streptococcus pneumoniae pilus-1 displays a biphasic expression pattern.
PloS one - 1 Jan 2011
De Angelis Gabriella, Moschioni Monica, Muzzi Alessandro, Pezzicoli Alfredo, Censini Stefano, Delany Isabel, Lo Sapio Morena, Sinisi Antonia, Donati Claudio, Masignani Vega, Barocchi Michèle A
Abstract excerpt
The Streptococcus pneumoniae pilus-1 is encoded by pilus islet 1 (PI-1), which has three clonal variants (clade I, II and III) and is present in about 30% of clinical pneumococcal isolates. In vitro and in vivo assays have demonstrated that pilus-1 is involved in attachment to epithelial cells and virulence, as well as protection in mouse models of infection. Several reports suggest that pilus-1 expression is...
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