Article
Expression of the type 1 pneumococcal pilus is bistable and negatively regulated by the structural component RrgA.
Infection and immunity - 1 Aug 2011
Basset Alan, Turner Keith H, Boush Elizabeth, Sayeed Sabina, Dove Simon L, Malley Richard
Abstract excerpt
The pneumococcal type 1 pilus, which is present in 25 to 30% of clinical isolates, has been associated with increased adherence and inflammatory responses and is being evaluated as a potential vaccine candidate. Here we show that expression of the pilus is bistable as a result of the molecular interaction between the transcription activator RrlA and a structural component of the pilus called RrgA. Sampling...
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