Article

The transcriptional legacy of developmental stochasticity

2019-12-12

Abstract excerpt

Genetic variation, epigenetic regulation and major environmental stimuli are key contributors to phenotypic variation, but the influence of minor perturbations or “noise” has been difficult to assess in mammals. In this work, we uncover one major axis of random variation with a large and permanent influence: developmental stochasticity. By assaying the transcriptome of wild monozygotic quadruplets of the nine-band...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5e6c3bd-3c4b-5d83-ba01-77b537124f64
DOI: 10.1101/2019.12.11.873265

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The transcriptional legacy of developmental stochasticityDOI 10.1101/2019.12.11.873265Read

The transcriptional legacy of developmental stochasticity.Semantic proximity Read

Stochastic developmental variation, an epigenetic source of phenotypic diversity with far-reaching biological consequences.Semantic proximity Read

Developmental noise is an overlooked contributor to innate variation in psychological traitsSemantic proximity Read

Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.Semantic proximity Read

Monoallelic Gene Expression: Stochastic or Clonal? From Detection to Mechanisms and Clinical Significance.Semantic proximity Read

Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation.Semantic proximity Read

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.Semantic proximity Read

Epigenetics and the maintenance of developmental plasticity: extending the signalling theory frameworkSemantic proximity Read

Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease.Semantic proximity Read

The origins of variation: evolutionary insights from developmental science.Semantic proximity Read

Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differencesSemantic proximity Read

Genetic determinants of gene expression noise and its role in complex trait variationSemantic proximity Read