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Article

A novel role of the Dna2 translocase function in DNA break resection.

Genes & development - 1 Mar 2017

Miller Adam S, Daley James M, Pham Nhung Tuyet, Niu Hengyao, Xue Xiaoyu, Ira Grzegorz, Sung Patrick

Abstract excerpt

DNA double-strand break repair by homologous recombination entails nucleolytic resection of the 5' strand at break ends. Dna2, a flap endonuclease with 5'-3' helicase activity, is involved in the resection process. The Dna2 helicase activity has been implicated in Okazaki fragment processing during DNA replication but is thought to be dispensable for DNA end resection. Unexpectedly, we found a requirement for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28336516
DOI: 10.1101/gad.295659.116
PMCID: PMC5393064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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