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Article

Rpb9 subunit controls transcription fidelity by delaying NTP sequestration in RNA polymerase II.

The Journal of biological chemistry - 17 Jul 2009

Walmacq Celine, Kireeva Maria L, Irvin Jordan, Nedialkov Yuri, Lubkowska Lucyna, Malagon Francisco, Strathern Jeffrey N, Kashlev Mikhail

Abstract excerpt

Rpb9 is a small non-essential subunit of yeast RNA polymerase II located on the surface on the enzyme. Deletion of the RPB9 gene shows synthetic lethality with the low fidelity rpb1-E1103G mutation localized in the trigger loop, a mobile element of the catalytic Rpb1 subunit, which has been shown to control transcription fidelity. Similar to the rpb1-E1103G mutation, the RPB9 deletion substantially enhances NTP...

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Identifiers

PMID: 19439405
DOI: 10.1074/jbc.M109.006908
PMCID: PMC2740586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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