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Article

Loss of cardiolipin leads to longevity defects that are alleviated by alterations in stress response signaling.

The Journal of biological chemistry - 3 Jul 2009

Zhou Jingming, Zhong Quan, Li Guiling, Greenberg Miriam L

Abstract excerpt

Perturbation of cardiolipin (CL) synthesis in yeast cells leads to defective respiratory chain function and mitochondrial DNA loss, both of which have been implicated in aging in mammals. The availability of yeast CL mutants enabled us to directly investigate the role of CL synthesis in aging. In this report, we show that the replicative life span of pgs1Delta, which lacks both CL and the precursor...

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Identifiers

PMID: 19401462
DOI: 10.1074/jbc.M109.003236
PMCID: PMC2709391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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