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Article

Analysis of 2'-O-methylated nucleosides and pseudouridines in ribosomal RNAs using DNAzymes.

Analytical biochemistry - 1 Feb 2007

Buchhaupt Markus, Peifer Christian, Entian Karl-Dieter

Abstract excerpt

Ribosomal RNAs (rRNAs) contain a large number of posttranscriptionally modified nucleosides, the physiological function of which is still unclear. The great majority of modifications in eukaryotes and archaea are 2'-O-ribose methylated nucleosides and pseudouridines. The current methods to identify rRNA modifications are difficult to perform and need expensive reagents. Here we report an easy method to detect...

Topics

Base Sequence
DNA, Catalytic
Genotype
Indicators and Reagents
Methylation
Molecular Sequence Data
Nucleosides
Pseudouridine
RNA Processing, Post-Transcriptional
RNA, Fungal
RNA, Ribosomal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Source

Identifiers

PMID: 17181990
DOI: 10.1016/j.ab.2006.11.001

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