Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.

The Journal of allergy and clinical immunology - 1 Sept 2011

Audry Magali, Ciancanelli Michael, Yang Kun, Cobat Aurelie, Chang Huey-Hsuan, Sancho-Shimizu Vanessa, Lorenzo Lazaro, Niehues Tim, Reichenbach Janine, Li Xiao-Xia, Israel Alain, Abel Laurent, Casanova Jean-Laurent, Zhang Shen-Ying, Jouanguy Emmanuelle, Puel Anne

Abstract excerpt

BACKGROUND: Children with germline mutations in Toll-like receptor 3 (TLR3), UNC93B1, TNF receptor-associated factor 3, and signal transducer and activator of transcription 1 are prone to herpes simplex virus-1 encephalitis, owing to impaired TLR3-triggered, UNC-93B-dependent, IFN-α/β, and/or IFN-λ-mediated signal transducer and activator of transcription 1-dependent immunity. OBJECTIVE: We explore here the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to I-kappa B Kinase

Share to Interferon Regulatory Factor-3

Share to NF-kappa B

Share to Signal Transduction

Share to Simplexvirus

Share to Toll-Like Receptor 3

Source

Open in PubMed Open full text

Identifiers

PMID: 21722947
DOI: 10.1016/j.jaci.2011.04.059
PMCID: PMC3164951

Genes

TLR3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.PMID 21722947Read ↗

Mendelian predisposition to herpes simplex encephalitis.Semantic proximity Read ↗

Genetic susceptibility to herpes simplex virus 1 encephalitis in mice and humans.Semantic proximity Read ↗

Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.Semantic proximity Read ↗

Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.Semantic proximity Read ↗

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity.Semantic proximity Read ↗

Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiencySemantic proximity Read ↗

Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene.Semantic proximity Read ↗

Herpes simplex virus encephalitis of childhood: inborn errors of central nervous system cell-intrinsic immunity.Semantic proximity Read ↗

TLR3 deficiency in patients with herpes simplex encephalitis.Semantic proximity Read ↗

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.Semantic proximity Read ↗

Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.Semantic proximity Read ↗

Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.