Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian predisposition to herpes simplex encephalitis.

Handbook of clinical neurology - 1 Jan 2013

Zhang Shen-Ying, Abel Laurent, Casanova Jean-Laurent

Abstract excerpt

Herpes simplex encephalitis (HSE) is the most common sporadic viral encephalitis in the Western world. The pathogenesis of HSE, which affects a small minority of HSV-1-infected individuals, has long remained elusive. Mendelian defects in the TLR3-interferon (IFN) and IFN-responsive pathways were recently shown to predispose to HSE, at least in some children. Autosomal recessive STAT-1 deficiency and X-linked NEMO...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to TLR3 gene
Share to Genetic Predisposition to Disease
Share to Herpesvirus 1, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant

Share to Membrane Transport Proteins

Share to Mutation

Share to STAT1 Transcription Factor

Share to Toll-Like Receptor 3

Source

Identifiers

PMID: 23622315
DOI: 10.1016/B978-0-444-52910-7.00027-1

Genes

TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian predisposition to herpes simplex encephalitis.PMID 23622315Read ↗

Herpes simplex virus encephalitis of childhood: inborn errors of central nervous system cell-intrinsic immunity.Semantic proximity Read ↗

Genetic susceptibility to herpes simplex virus 1 encephalitis in mice and humans.Semantic proximity Read ↗

Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiencySemantic proximity Read ↗

[Genetic susceptibility to herpes simplex encephalitis].Semantic proximity Read ↗

Herpes simplex virus encephalitis in human UNC-93B deficiency.Semantic proximity Read ↗

Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.Semantic proximity Read ↗

NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.Semantic proximity Read ↗

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity.Semantic proximity Read ↗

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.Semantic proximity Read ↗

Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense.Semantic proximity Read ↗

IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary ImmunodeficienciesSemantic proximity Read ↗

[Clinical characteristics, prognosis and genetic susceptibility of herpes simplex encephalitis in children].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.