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Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency

14 Apr 2023

Abstract excerpt

Inborn errors of TLR3-dependent type I IFN immunity in cortical neurons underlie forebrain herpes simplex virus-1 (HSV-1) encephalitis (HSE) due to uncontrolled viral growth and subsequent cell death. We report an otherwise healthy patient with HSE who was compound heterozygous for nonsense (R422*) and frameshift (P493fs9*) RIPK3 variants. Receptor-interacting protein kinase 3 (RIPK3) is a ubiquitous cytoplasmic...

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PMID: 37083451
DOI: 10.1126/sciimmunol.ade2860

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