Article
The processed pseudogene of mouse thymidine kinase is active after transfection.
FEBS letters - 17 Sept 1990
Seiser C, Beck G, Wintersberger E
Abstract excerpt
Aside of the gene coding for cytoplasmic thymidine kinase, the genome of mouse cells carries two pseudogenes. Both are inactive in situ. One of the pseudogenes is a processed pseudogene in which a two base pair deletion caused a shift of the reading frame and a shortening of the gene product from the 233 amino acids of thymidine kinase to 177 amino acids in the pseudogene product. We report here that introduction...
Topics
- Animals
- Cells, Cultured
- Clone Cells
- Gene Amplification
- Gene Expression Regulation, Enzymologic
- Glucocorticoids
- Mammary Tumor Virus, Mouse
- Mice
- Phenotype
- Promoter Regions, Genetic
- Pseudogenes