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Article

An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene.

Nature - 1 May 2003

Hirotsune Shinji, Yoshida Noriyuki, Chen Amy, Garrett Lisa, Sugiyama Fumihiro, Takahashi Satoru, Yagami Ken-ichi, Wynshaw-Boris Anthony, Yoshiki Atsushi

Abstract excerpt

A pseudogene is a gene copy that does not produce a functional, full-length protein. The human genome is estimated to contain up to 20,000 pseudogenes. Although much effort has been devoted to understanding the function of pseudogenes, their biological roles remain largely unknown. Here we report the role of an expressed pseudogene-regulation of messenger-RNA stability-in a transgene-insertion mouse mutant...

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PMID: 12721631
DOI: 10.1038/nature01535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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