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Article

A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes.

Human molecular genetics - 1 Jan 2010

Ratelade Julien, Arrondel Christelle, Hamard Ghislaine, Garbay Serge, Harvey Scott, Biebuyck Nathalie, Schulz Herbert, Hastie Nick, Pontoglio Marco, Gubler Marie-Claire, Antignac Corinne, Heidet Laurence

Abstract excerpt

The Wilms tumor-suppressor gene WT1, a key player in renal development, also has a crucial role in maintenance of the glomerulus in the mature kidney. However, molecular pathways orchestrated by WT1 in podocytes, where it is highly expressed, remain unknown. Their defects are thought to modify the cross-talk between podocytes and other glomerular cells and ultimately lead to glomerular sclerosis, as observed in...

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Share to Cytochrome P-450 Enzyme System
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Regulatory Sequences, Nucleic Acid

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Source

Identifiers

PMID: 19797313
DOI: 10.1093/hmg/ddp462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes.PMID 19797313Read ↗

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