Trichostatin A Modified Histone Covalent Pattern and Enhanced Expression of Pluripotent Genes in Interspecies Black-Footed Cat Cloned Embryos But Did Not Improve <i>In Vitro</i> and <i>In Vivo</i> Viability

Abstract excerpt

Abstract The black-footed cat (BFC; Felis nigripes), one of the smallest wild cats, is listed as threatened. Interspecies somatic cell nuclear transfer (Is-SCNT) offers the possibility of preserving endangered species. Development to term of interspecies BFC (Is-BFC) cloned embryos has not been obtained, possibly due to abnormal epigenetic reprogramming. Treatment of intraspecies cloned embryos with TSA improves...

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