Article
Normal location of thumb/big toe may be related to programmed cell death in the preaxial area of embryonic limb.
Anatomical record (Hoboken, N.J. : 2007) - 1 Aug 2011
Kimura Sumiko, Yamada Shigehito, Naruse Ichiro
Abstract excerpt
The forelimbs and hindlimbs of newborn Polydactyly Nagoya (Pdn) mice were examined to analyze the roles of programmed cell death (PCD) in the preaxial region of the limb. Special attention was paid to the relationship between the PCD in the preaxial area and the location and shape of the first digit (thumb/big toe). Although a large, bifurcated or duplicated thumb/big toe appeared in Pdn/+ mice, digit I...
Topics
- Animals
- Animals, Newborn
- Apoptosis
- Disease Models, Animal
- Forelimb
- Heterozygote
- Hindlimb
- Homozygote
- Kruppel-Like Transcription Factors
- Mice
- Mice, Mutant Strains
- Morphogenesis
- Mutation
- Nerve Tissue Proteins
- Phenotype
- Polydactyly
- Zinc Finger Protein Gli3