Programmed cell death is affected in the novel mouse mutant Fused toes (Ft).

doi:10.1242/dev.120.9.2601

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Article

Programmed cell death is affected in the novel mouse mutant Fused toes (Ft).

Development (Cambridge, England) - 1 Sept 1994

van der Hoeven F, Schimmang T, Volkmann A, Mattei M G, Kyewski B, Rüther U

Abstract excerpt

We have identified a novel dominant mouse mutant that is characterised by fused toes on the fore limbs and a thymic hyperplasia, in heterozygous animals. Homozygosity of the mutation leads to malformation of the developing brain, lost of the genetic control of left-right asymmetry and to death ar...

Topics

Animals
Apoptosis
Chromosome Mapping
Chromosomes
Extremities
Genes, Dominant
Mice
Mice, Mutant Strains
Morphogenesis
Phenotype
Thymus Gland

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