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Article

Association of genetic risk and physical activity with incident type 2 diabetes.

The Journal of clinical endocrinology and metabolism - 15 Jul 2026

Zhou Xuan, Carrasquilla Germán D, Christiansen Malene R, Smit Roelof A J, Ängquist Lars, Hansen Torben, Loos Ruth J F, Grarup Niels, Linneberg Allan, Kilpeläinen Tuomas O, Merino Jordi

Abstract excerpt

OBJECTIVE: The aim of this study was to assess whether daily step counts and genetic risk interact to influence the risk of developing type 2 diabetes. RESEARCH DESIGN AND METHODS: We analyzed data from 9501 participants in the All of Us Research Program with both genetic and wearable device-derived physical activity data and without diabetes at baseline and a median age of 56 years (42-66). Physical activity was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41761698
DOI: 10.1210/clinem/dgag083
PMCID: PMC13368372

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