Article
Acrolein induced DNA damage, mutagenicity and effect on DNA repair.
Molecular nutrition & food research - 1 Sept 2011
Tang Moon-shong, Wang Hsiang-tsui, Hu Yu, Chen Wei-Sheng, Akao Makoto, Feng Zhaohui, Hu Wenwei
Abstract excerpt
Acrolein (Acr) is a ubiquitous environmental contaminant; it also can be generated endogenously by lipid peroxidation. Acr contains a carbonyl group and an olefinic double bond; it can react with many cellular molecules including amino acids, proteins and nucleic acids. In this review article we focus on updating information regarding: (i) Acr-induced DNA damage and methods of detection, (ii) repair of Acr-DNA...
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