Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases.

doi:10.1080/10937404.2011.556051

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Article

Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases.

Journal of toxicology and environmental health. Part B, Critical reviews - 1 Jan 2011

Huang Sarah X L, Jaurand Marie-Claude, Kamp David W, Whysner John, Hei Tom K

Abstract excerpt

The cellular and molecular mechanisms of how asbestos fibers induce cancers and other diseases are not well understood. Both serpentine and amphibole asbestos fibers have been shown to induce oxidative stress, inflammatory responses, cellular toxicity and tissue injuries, genetic changes, and epigenetic alterations in target cells in vitro and tissues in vivo. Most of these mechanisms are believe to be shared by...

Topics

Animals
Asbestos
Asbestosis
Carcinogens, Environmental
Chemical Phenomena
DNA Damage
Humans
Mineral Fibers
Mitosis
Mutation
Neoplasms
Pleural Diseases

Source

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Identifiers

PMID: 21534089
DOI: 10.1080/10937404.2011.556051
PMCID: PMC3118525

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